My current research directions are to investigate mechanisms governing actions of angiogenic factors on fetoplacental vasculature with a specific interest in the intracellular signaling pathways. Specific research projects include 1) determining whether in the fetoplacenta bFGF- & VEGF-induced angiogenesis is modulated in part via an increase in production of nitric oxide which in turn activates MEK/ERK and PI3K/Akt signal pathways and increases expression of bFGF & VEGF as well as their receptors; 2) determining whether newly identified VEGF receptor, neuropilin-1 and –2, are expressed in endothelial cells and their roles in placental angiogenesis and vasodilators; and 3) exploring roles of angiotensin II in regulation of angiogenesis and vasodilation. In addition, another area of Dr. Zheng’s research is to study the mechanisms underlying endothelial differentiation from human embryonic stem cells.
- Joined ERP Program: 2001
- Animal Sciences 875 – Endocrine Physiology
- Animal Sciences 875 – Pregnancy, Parturition, and Lactation
- Member – Endocrinology and Reproductive Physiology Admissions Committee
- PI NIH 2R01HL64703 4/1/05-3/30/09 Effects of Nitric Oxide on FetoPlacental Angiogenesis
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