The Golos laboratory examines questions of placental biology relevant to human health and disease, using nonhuman primate models, human clinical materials, and human and nonhuman primate embryonic stem cells in their studies. Study of the maternal-fetal immune dialogue examines nonpolymorphic MHC class I molecules expressed on placental cells and their interactions with the maternal immune system, particularly endometrial natural killer cells and macrophages in promoting pregnancy success, including placental and decidual vascularization. In addition, embryonic stem cells and primate embryos are used to model implantation and placental morphogenesis, with 2-dimensional and 3-dimensional modeling and co-culture systems for understanding how placental cells carry on a dialog with the maternal endometrium. At the interface of these projects is the effect of maternal immune cells directly on rhesus blastocyst function and growth in 3-dimensional co-culture.
Maternal immune recognition of pregnancy, and regulation of a healthy implantation site and placenta, may play a significant role in pregnancy issues ranging from miscarriage and recurrent pregnancy loss to preeclampsia and intrauterine growth restriction. The primate model will allow direct experimentation at the maternal-fetal interface to develop experimental and therapeutic models of utero-placental function and dysfunction.
- Joined ERP Program: 1995
- Animal Sciences 875: Endocrine Physiology
- Member – Endocrinology & Reproductive Physiology Program NIH T32 Predoctoral Steering Committee
- PI NIH/ORIP R24 OD019803-01 05/01/15-04/30/19 Transgenic Marmosets for Translational Stem Cell Research
- PI NIH R21 AI100156-01A1 08/12/13-06/30/15 Primate Placental Immunogenetics
- PI NIH R01 AI107157-01A1 08/01/14-07/31/18 The Maternal-Fetal Interface in Listeria-Induced Pregnancy Loss
- Co-Investigator NIH U01 HD087216-01 10/01/15-09/30/19 Advanced MRI for Uteroplacental Flow, Perfusion, Oxygenation & Inflammation
- NIH P51 OD011106-53 05/01/2013-04/30/2017 Wisconsin National Primate Research Center
|Current Trainees||Degree Goal|
|Past Trainees||Degree Completed|
|Tien-cheng (Arthur) Chang||PhD|