Dudley Lamming
Associate Professor, Medicine
Education
B.S. 2000 Massachusetts Institute of Technology, Cambridge, MA
Ph. D. 2008 Harvard University, Cambridge, MA
Postdoctoral Position 2013 Whitehead Institute for Biomedical Research, Cambridge, MA
Biography
NIH Biosketch
PubMed Publications
Department Website
Research Focus
Our laboratory is focused on understanding how what, when, and how much we eat can regulate metabolic health and aging. We discovered that low protein diets promote metabolic health and lifespan – improving blood sugar control and reducing adiposity – in humans and mice, and we have identified dietary branched-chain amino acids (BCAA) as key regulators of these effects. We currently study the mechanisms that mediate these beneficial effects, with an emphasis on understanding the role of the amino acid responsive kinase mTOR (the mechanistic Target of Rapamycin). We also study if altering mTOR signaling with rapamycin, novel rapamycin derivatives, and other geroprotective agents can be used to treat or prevent age-related diseases, including diabetes and Alzheimer’s disease.
Program Activities
- Joined ERP Program: 2014
- Teaching:
- Medicine 720: Endocrinology & Metabolism
- ERP Steering Committee Member
- ERP T32 Training Partner
Trainees
Current ERP students
- Yang Liu (PhD in progress)
Prior ERP students
- Nicole Richardson, PhD
- Mohammed Alotaibi, MS