Position title: Associate Professor, Pediatrics
Phone: Sex differences in developmental neuroprotection; Roles played by estrogen receptors and neuroestrogens in the hippocampus
MD 1996 Marmara University School of Medicine, Istanbul, Turkey
Residency: Louisiana State University Medical Center - Shreveport, LA
Dr. Pelin Cengiz’s research focuses on finding a novel therapy for neonatal encephalopathy subsequent to hypoxic ischemic brain injury [hypoxia-ischemia (HI)]. She uses the experimental (Vannucci-Rice) mouse model of hypoxia ischemia (HI) to study the sexually differentiated role of estrogen receptor alpha and neurotrophin signaling in the neonatal hippocampus post-HI. The neurotrophin receptor, tyrosine kinase B (TrkB), plays an important role in neuroprotection and improving the long-term functional recovery following HI by increasing neuronal survival. She has shown that administration of 7,8 dihydroxyflavone (7,8-DHF; potent and selective TrkB agonist) increases TrkB phosphorylation and hippocampal neuronal survival following HI in female, but not in male newborn mice. Her recent studies have implicated estrogen receptor alpha in conferring this sex-specific neuroprotective mechanism. Her current studies focus on the cellular mechanisms of the role of estrogen receptor alpha following HI in developing brains.
- Joined ERP Program: 2020
No past or current ERP student trainees