Biography NIH Biosketch PubMed Publications Department Website Research Focus I have over 30 years of experience employing animal models of female reproductive endocrinology to determine pathophysiological mechanisms underlying a variety of reproductive health disorders commonly found in women. Currently, there are two main areas of research focus: polycystic ovary syndrome (PCOS) afflicting up to 15% …
Biography NIH Biosketch PubMed Publications Department Website Research Focus A major focus of my laboratory is to define the regulatory mechanisms that control vesicle biogenesis and membrane remodeling in the endocytic and secretory pathways of metazoan cells. Program Activities Trainees No current ERP students Past ERP students
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus Control of pregnancy-induced changes in cell function / endocrine signaling in response to growth factor and heptahelical receptor agonists by uterine artery endothelium. Control of adrenal zonation and function by Angiotensin II and integration of adrenal and gonadal steroidogenesis in higher mammals/humans. Gestational development of zonation …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus Since 1994 my research has focused on the relationships between diet, body composition and energy metabolism in nonhuman primates. I have developed and standardized techniques required to fully elucidate metabolic function in nonhuman primates such as detailed assessments of food intake, body composition, glucoregulatory function, energy …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus Background: The Davis Lab is interested in pancreatic beta cell biology. Specifically, we have been focused on understanding the mechanisms underlying the proliferative response in the beta cell. Beta cells are normally in a quiescent state, but can be stimulated to divide and expand in response …
Biography NIH Biosketch PubMed Publications Department Website Research Focus The overall goal of our laboratory is to understand how autocrine/paracrine factors in the mammary gland regulate mammary gland development, as well as milk synthesis and secretion. We utilize a combination of in vitro and in vivo models, with a variety of mammalian species (mice, cattle, …
Biography NIH Biosketch PubMed Publications Research Focus Our research addresses signaling mechanisms involving P450 cytochromes. These regulate activity at nuclear receptors regulated by three types of activator: cholesterol/steroid hormones fatty acids; metabolites Ah receptor/PCB’s; and polycyclic aromatic hydrocarbons. Program Activities Trainees No current ERP students Past ERP students
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus The Jorgensen lab uses cell and molecular biology tools to identify genes that are sexually dimorphic during sex differentiation, characterize their functional significance, and finally, understand how they are regulated. Currently, we are focusing on two genes: steroidogenic factor 1 (Sf1) and Iroquois homeobox factor 3 …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus My research program is focused on two major fields. The first is applied research on candidate genes affecting production and reproduction traits in cattle. The second is basic research on the mechanisms leading to differential expression of monoallelically- versus biallelically-expressed genes, including imprinted genes. Program Activities …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus Dr. Kimple leads a multi-level research team whose focus is on understanding how the beta-cells of the pancreas respond to nutrient and hormonal stimulation to affect biological changes. Her group is especially interested in elucidating how dysfunctional G protein-coupled receptor signaling pathways contribute to the pathogenesis …