Biography NIH Biosketch Publications Laboratory Website Research Focus My laboratory examines questions of vascular and placental biology relevant to human health and disease. We use both animal models as well as human clinical materials in our studies. Under this broad focus, research areas include: These studies will offer exciting insights in understanding the mechanisms that …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus For the past 30 years I have studied the neuroendocrine regulation of gonadotropin releasing hormone (GnRH) neurons, in part by developing and utilizing physiological methods to monitor and analyze GnRH neurosecretion in awake animals. My research has also focused on the mechanisms by which ovarian steroids …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus My research is focused on molecular mechanisms underlying vascular inflammation, molecular mechanisms underlying occlusive vascular diseases, and development of new materials for biomedical applications (gene delivery and vascular grafts). Program Activities Trainees No current ERP students
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus The primary focus of my research is to devise specific methods for early diagnosis of epithelial ovarian cancer (EOC) and to understand the effect of factors produced by ovarian tumors on the functional capacity of tumor infiltrating lymphocytes. This research involves extensive utilization of glycoproteomic analysis …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus Understand the mechanism of Kir7.1 mutations associated blindness using patient derived iPS-Retinal Pigment Epithelium cells. Kir7.1 potassium channels are present in the apical processes of RPE cell that mediate ionic homeostasis within the retina structure and several mutations are associated with childhood blindness. Our primary goal …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus Exciting new advances in DNA sequencing technology have begun to reveal the depth and significance of genomic variation among organisms. The causes of this variation are evolutionary, and the rapid accumulation of data on the genomic scale has firmly positioned population and evolutionary geneticists at the …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus The goal of our research program is to understand at the cellular and molecular level processes involved in early vertebrate development, specifically but not exclusively the functional diversification of cell types. Program Activities Trainees No Current ERP students Past ERP students
Biography NIH Biosketch PubMed Publications Research Focus The Schuler laboratory is interested in the role of prolactin and its crosstalk with other hormones and growth factors in development and progression of breast cancer. Program Activities Trainees No current ERP students
Biography NIH Biosketch PubMed Publications Research Focus My area of research interest is mechanisms of preeclamptic hypertension, which obviously has broad relevanced to the physiology and patholphysiology of reproduction. We have investigated rennin secretion from chrorionic cells and steroid-mediated regulation of rennin secretion in stromal/decidual cells. We have contributed significantly to the concept that there …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus Our research program is dedicated unraveling the cellular networks underlying preeclampsia, intrauterine growth restriction, recurrent pregnancy loss and implantation failure in Assisted Reproductive Technologies. Our lab employs both human and mouse models of reproductive physiology and disease. We use genetic targeting of immune cell development and …