Biography NIH Biosketch PubMed Publications Departmental Website Research Focus The Jorgensen lab uses cell and molecular biology tools to identify genes that are sexually dimorphic during sex differentiation, characterize their functional significance, and finally, understand how they are regulated. Currently, we are focusing on two genes: steroidogenic factor 1 (Sf1) and Iroquois homeobox factor 3 …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus My research program is focused on two major fields. The first is applied research on candidate genes affecting production and reproduction traits in cattle. The second is basic research on the mechanisms leading to differential expression of monoallelically- versus biallelically-expressed genes, including imprinted genes. Program Activities …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus Dr. Kimple leads a multi-level research team whose focus is on understanding how the beta-cells of the pancreas respond to nutrient and hormonal stimulation to affect biological changes. Her group is especially interested in elucidating how dysfunctional G protein-coupled receptor signaling pathways contribute to the pathogenesis …
Biography NIH Biosketch PubMed Publications Department Website Research Focus How cells respond to information from their surroundings and use this information to make decisions. The Kreeger lab utilizes systems biology and tissue engineering to analyze this question in the context of women’s health, particularly breast cancer, ovarian cancer, and endometriosis. We utilize an iterative approach, …
Biography NIH Biosketch Publications Laboratory Website Research Focus My laboratory examines questions of vascular and placental biology relevant to human health and disease. We use both animal models as well as human clinical materials in our studies. Under this broad focus, research areas include: These studies will offer exciting insights in understanding the mechanisms that …
Biography NIH Biosketch PubMed Publications Department Website Research Focus Our laboratory is focused on understanding how what, when, and how much we eat can regulate metabolic health and aging. We discovered that low protein diets promote metabolic health and lifespan – improving blood sugar control and reducing adiposity – in humans and mice, and we …
Biography NIH Biosketch PubMed Publications Department Website Research Focus Dr. Laporta’s research focuses on two main areas: 1) understanding how autocrine, systemic, and environmental factors affect mammary gland developmental trajectory and function in dairy cows, and 2) how prenatal (in-utero) and early postnatal (pre-weaning) nutritional and environmental influences program the developing calf long term. Dr. …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus For the past 30 years I have studied the neuroendocrine regulation of gonadotropin releasing hormone (GnRH) neurons, in part by developing and utilizing physiological methods to monitor and analyze GnRH neurosecretion in awake animals. My research has also focused on the mechanisms by which ovarian steroids …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus My research is focused on molecular mechanisms underlying vascular inflammation, molecular mechanisms underlying occlusive vascular diseases, and development of new materials for biomedical applications (gene delivery and vascular grafts). Program Activities Trainees No current ERP students
Biography NIH Biosketch PubMed Publications Department Website Research Focus: The Meyer lab studies the dynamic chromatin environment responsible for serum calcium and phosphate maintenance and the impacts of vitamin D metabolism in skeletal, renal, and intestinal biology. A triumvirate of endocrine hormones – parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), and calcitriol (1,25(OH)2D3) – …