Biography NIH Biosketch PubMed Publications Departmental Website Research Focus Dendritic spines are the sites of most excitatory connections in the central nervous system. The central goal of my laboratory is to delineate the molecular and biochemical mechanisms that regulate dendritic spine plasticity in both the normal and diseased brain. In particular, using animal models, I …
Biography PubMed Publications Departmental Website Research Focus Dr. Pelin Cengiz’s research focuses on finding a novel therapy for neonatal encephalopathy subsequent to hypoxic ischemic brain injury [hypoxia-ischemia (HI)]. She uses the experimental (Vannucci-Rice) mouse model of hypoxia ischemia (HI) to study the sexually differentiated role of estrogen receptor alpha and neurotrophin signaling in the neonatal …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus Since 1994 my research has focused on the relationships between diet, body composition and energy metabolism in nonhuman primates. I have developed and standardized techniques required to fully elucidate metabolic function in nonhuman primates such as detailed assessments of food intake, body composition, glucoregulatory function, energy …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus Background: The Davis Lab is interested in pancreatic beta cell biology. Specifically, we have been focused on understanding the mechanisms underlying the proliferative response in the beta cell. Beta cells are normally in a quiescent state, but can be stimulated to divide and expand in response …
Biography NIH Biosketch PubMed Publications Department Website Research Focus: The Dominko Lab focuses on the effects of tissue environment on fibroblast behaviors during wound healing. We are interested in the molecular mechanisms responsible for oxygen and growth factor signaling during switching between pro-fibrotic and pro-regenerative cell phenotype, the role of extracellular matrix in cell fate …
Biography NIH Biosketch PubMed Publications Department Website Research Focus: My research focuses on understanding and developing treatments for neurological disorders, in particular Parkinson’s disease, in a highly collaborative, interdisciplinary fashion. We aim to create animal models and experimental paradigms that better reflect patients’ clinical conditions. We apply advanced imaging techniques to minimize invasive procedures, maximize …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus The endoplasmic reticulum (ER) is a dynamic organelle that plays a key role for cellular homeostasis, development, and stress responsiveness. In response to cellular stress induced by toxins, unfolded proteins and inflammation, a well-established signaling cascade, the unfolded protein response (UPR), is activated. During UPR, perturbations …
Biography NIH Biosketch PubMed Publications Department Website Research Focus: Research in the Galmozzi lab is split between gaining a deep understanding of fundamental processes in cell biology and studying the molecular basis of adipose tissue dysfunction in metabolic diseases, such as obesity, Type 2 diabetes, and cancer-associated cachexia. The team uses a multidisciplinary approach that …
Biography NIH Biosketch PubMed Publications Department Website Research Focus: My lab focuses on the mechanistic intersection between bariatric surgery, metabolism, and aging. Using complex surgical models in mice, we explore how bariatric surgery mitigates metabolic disease, obesity-associated organ dysfunction, and age-related illness. The lab’s overarching goal is to uncover novel targets to treat obesity and …
Biography NIH Biosketch PubMed Publications Department Website Research Focus The overall goal of our laboratory is to understand how autocrine/paracrine factors in the mammary gland regulate mammary gland development, as well as milk synthesis and secretion. We utilize a combination of in vitro and in vivo models, with a variety of mammalian species (mice, cattle, …