Biography NIH Biosketch PubMed Publications Department Website Research Focus I have over 30 years of experience employing animal models of female reproductive endocrinology to determine pathophysiological mechanisms underlying a variety of reproductive health disorders commonly found in women. Currently, there are two main areas of research focus: polycystic ovary syndrome (PCOS) afflicting up to 15% …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus Obesity is a world-wide problem, and two-thirds of the population in the United States is currently considered to be either overweight or obese. Obesity increases the risk for multiple different types of cancer. In particular, obesity significantly increases the risk for postmenopausal breast cancer. Obesity also …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus The Arriola-Apelo lab focuses on mechanistic mathematical models of nutrient metabolism and cellular signaling, with the major goal of maximizing nutrient efficiency for a sustainable dairy industry. His group is particularly interested in the role of the protein kinase mTOR on nutrient and hormonal regulation of …
Biography NIH Biosketch PubMed Publications Department Website Research Focus The Laboratory for Endocrinology, Aging and Disease (LEAD) focuses on understanding the endocrinology of aging as elaborated upon in ‘The Reproductive–Cell Cycle Theory of Aging’. Research examines the pivotal role of reproductive hormones in regulating embryogenesis, maintenance of adult tissues and age-related diseases, and the translation of these basic findings …
Biography NIH Biosketch PubMed Publications Department Website Research Focus A major focus of my laboratory is to define the regulatory mechanisms that control vesicle biogenesis and membrane remodeling in the endocytic and secretory pathways of metazoan cells. Program Activities Trainees No current ERP students Past ERP students
Biography NIH Biosketch PubMed Publications Department Website Research Focus: Epigenetic organization of juvenile brain and behavior: Do sex differences in neuroepigenetic mechanisms mediate risk or resilience to the impact of early-life adversity on juvenile mental health disorders? The study of epigenetics allows for the understanding of how early gene x environmental interactions can shape lasting …
Biography NIH Biosketch PubMed Publications Department Website Research Focus My research program focuses on families and children with autism spectrum disorder. I study daily occupations, specifically eating and mealtimes, to elucidate the impact on the child’s health, family wellness, and overall daily participation. I also study sensory features in children with autism spectrum disorder, including …
Biography NIH Biosketch PubMed Publications Department Website Research Focus The Baker Lab studies the domestic dog as a model for complex hereditary disorders to efficiently identify genetic and environmental risk factors for initiation and progression of disease. We utilize a variety of statistical and bioinformatic approaches to analyze and integrate large-scale ‘omics datatypes, including genomics, …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus Control of pregnancy-induced changes in cell function / endocrine signaling in response to growth factor and heptahelical receptor agonists by uterine artery endothelium. Control of adrenal zonation and function by Angiotensin II and integration of adrenal and gonadal steroidogenesis in higher mammals/humans. Gestational development of zonation …
Biography NIH Biosketch PubMed Publications Departmental Website Research Focus How does a newly formed stem or progenitor cell “know” it had reached its full differentiation capacity, and should assume its mature function? What part of the signal towards terminal differentiation comes from the cell’s interactions with its surrounding environment, and what is encoded in the …